HMEC-1 endothelial cell line response to infection by Rickettsia prowazekii
Summary:
Analysis of endothelial cells infected by R. prowazekii strains (Erus, Evir, Rp22) of varying virulence. Virulent R. prowazekii causes epidemic typhus and avirulent strains can revert to virulence. Results provide insight into the molecular basis of virulence and adaptive mutation in R. prowazekii.
GPL4133:
Agilent-014850 Whole Human Genome Microarray 4x44K G4112F (Feature Number version)
Citation:
Bechah Y, El Karkouri K, Mediannikov O, Leroy Q et al. Genomic, proteomic, and transcriptomic analysis of virulent and avirulent Rickettsia prowazekii reveals its adaptive mutation capabilities. Genome Res 2010 May;20(5):655-63. PMID: 20368341
