Analysis of primary cortical neurons stimulated with C1q. In vitro, C1q, in the absence of other complement proteins, improves neuronal viability, neurite outgrowth and prevents β-amyloid-induced neuronal death. Results provide insight into the molecular basis of the neuroprotective role of C1q.
GPL6247:
[RaGene-1_0-st] Affymetrix Rat Gene 1.0 ST Array [transcript (gene) version]
Citation:
Benoit ME, Tenner AJ. Complement protein C1q-mediated neuroprotection is correlated with regulation of neuronal gene and microRNA expression. J Neurosci 2011 Mar 2;31(9):3459-69. PMID: 21368058
