DataSet Record GDS3774: Expression Profiles Data Analysis Tools Sample Subsets
Title: microRNA-124 guide strand segmentation effect on HCT-116 Dicer hypomorph cells
Cluster AnalysisGDS3774 Cluster Image
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Summary: Analysis of HCT-116 dicer- cells transfected with miR-124 duplex containing a segmented guide strand. Following miRNA guide strand segmentation, seed-based (positions 2 through 8 at the 5' end of the guide strand) activity persisted. Results illustrate a structural flexibility in miRNA duplexes.
Organism: Homo sapiens
Platform: GPL10379: Rosetta/Merck Human RSTA Custom Affymetrix 2.0 microarray [HuRSTA-2a520709]
Citation:
  • Chorn G, Zhao L, Sachs AB, Flanagan WM et al. Persistence of seed-based activity following segmentation of a microRNA guide strand. RNA 2010 Dec;16(12):2336-40. PMID: 20971811
Reference Series: GSE25224 Sample count: 4
Value type: count Series published: 2010/11/12