Analysis of skeletal muscle (SM) from transgenics deficient in retinoic acid receptor-related orphan receptor (ROR) alpha 1delDE. SM accounts for significant levels of lipid catabolism; ROR alpha is involved in regulating lipid metabolism. Results provide insight into ROR alpha1 signaling in SM.
Raichur S, Fitzsimmons RL, Myers SA, Pearen MA et al. Identification and validation of the pathways and functions regulated by the orphan nuclear receptor, ROR alpha1, in skeletal muscle. Nucleic Acids Res 2010 Jul;38(13):4296-312. PMID: 20338882