Azaspiracid-1 effect on T lymphocyte cell line: time course and dose response
Summary:
Analysis of T lymphocyte Jurkat cells treated with 1 or 10 nM azaspiracid-1 (AZA-1) for up to 24 hours. AZA-1 is a marine biotoxin reported to accumulate in shellfish and is associated with severe gastrointestinal intoxication. Results provide insight into the mechanism of action of AZA-1.
GPL1708:
Agilent-012391 Whole Human Genome Oligo Microarray G4112A (Feature Number version)
Citation:
Twiner MJ, Ryan JC, Morey JS, Smith KJ et al. Transcriptional profiling and inhibition of cholesterol biosynthesis in human T lymphocyte cells by the marine toxin azaspiracid. Genomics 2008 Mar;91(3):289-300. PMID: 18191373
