MAP kinase PMK-1 and transcription factor DAF-16 deletion mutants
Summary:
Analysis of daf-2(e1368) loss-of-function mutant and daf-2(e1368);pmk-1(km25) and daf-2(e1368);daf-16(mgDf47) double mutants. PMK-1 and DAF-16 confer enhanced pathogen resistance on daf-2 mutants relative to wild-type. Results suggest DAF-16 and PMK-1 upregulate distinct genes to promote immunity.
GPL200:
[Celegans] Affymetrix C. elegans Genome Array
Citation:
Troemel ER, Chu SW, Reinke V, Lee SS et al. p38 MAPK regulates expression of immune response genes and contributes to longevity in C. elegans. PLoS Genet 2006 Nov 10;2(11):e183. PMID: 17096597
