Diethylstilbestrol effect on the prepubertal uterus: dose response
Summary:
Analysis of uteri of prepubertal animals treated with diethylstilbestrol (DES) at doses of 1, 10, or 1000 ug/kg/day. DES treatment of neonates results in the development of uterine adenocarcinomas. Results provide insight into the mechanisms underlying the initiation of DES-induced carcinogenesis.
GPL891:
Agilent-011978 Mouse Microarray G4121A (Feature Number version)
Citation:
Newbold RR, Jefferson WN, Grissom SF, Padilla-Banks E et al. Developmental exposure to diethylstilbestrol alters uterine gene expression that may be associated with uterine neoplasia later in life. Mol Carcinog 2007 Sep;46(9):783-96. PMID: 17394237
