Cannabinoid receptor double knockout mutant response to contact allergen
Summary:
Analysis of skins of mutants lacking 2 cannabinoid receptors after treatment with the contact allergen 2,4-dinitrofluorobenzene (DNFB). DNFB elicits a cutaneous T-cell mediated allergic response. Results provide insight into the role of the endocannabinoid system in allergic contact dermatitis.
Karsak M, Gaffal E, Date R, Wang-Eckhardt L et al. Attenuation of allergic contact dermatitis through the endocannabinoid system. Science 2007 Jun 8;316(5830):1494-7. PMID: 17556587
