Retinoblastomas with loss of heterozygosity at chromosome 16q
Summary:
Analysis of 4 retinoblastomas with loss of heterozygosity (LOH) at chromosome 16q. In addition to RB1 gene mutations, retinoblastomas frequently show gains of 1q and 6p and losses of 16q. Results identify candidate tumor suppressors on 16q in retinoblastoma.
GPL96:
[HG-U133A] Affymetrix Human Genome U133A Array
Citation:
Gratias S, Rieder H, Ullmann R, Klein-Hitpass L et al. Allelic loss in a minimal region on chromosome 16q24 is associated with vitreous seeding of retinoblastoma. Cancer Res 2007 Jan 1;67(1):408-16. PMID: 17210724
