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Series GSE5222 Query DataSets for GSE5222
Status Public on Jan 29, 2007
Title Expression data from retinoblastoma
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Genomic losses on chromosome 16q are among the most frequent alterations found in retinoblastoma. In this study, Affymetrix GeneChip analyses along with LOH analysis of microsatellie markers was used to identify candidate tumor suppressor loci in a set of retinoblastoma.
We used microarrays to identify genes differentially expressed in retinoblastoma with LOH on 16q (M19484, M22590, M22641, M22860) compared to retinoblastoma without alterations in this region (M20517, M22067, M22233, M23209, M23449, M23818, M23896, M23978)
Keywords: Disease progression
Overall design To compare the transcriptosomes of retinoblastoma with and without LOH on 16q, total RNA was isolated from a 30 mg block of each tumor and subjected to Affymetrix microarray analysis on HG-U133A arrays.
Contributor(s) Gratias S, Rieder H, Ullmann R, Klein-Hitpass L, Schneider S, Bölöni R, Kappler M, Lohmann DR
Citation(s) 17210724
Submission date Jul 03, 2006
Last update date Aug 10, 2018
Contact name Ludger Klein-Hitpass
Phone +49 201 723 85552
Organization name Institut fuer Zellbiologie
Department Universitaetsklinikum
Lab BioChip Lab
Street address Virchowstr. 173
City Essen
ZIP/Postal code D-45122
Country Germany
Platforms (1)
GPL96 [HG-U133A] Affymetrix Human Genome U133A Array
Samples (12)
GSM118316 Retinoblatoma M19484
GSM118317 Retinoblatoma M22590
GSM118318 Retinoblatoma M22641
BioProject PRJNA96519

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