Transcription factor p63 inactivation effect on squamous cells (HG-U133 2.0)
Summary:
Analysis of squamous cell lines following siRNA knockdown of the transcription factor p63, a homolog of the tumor suppressor p53. p63 encodes multiple isoforms that activate or repress transcription, and is critical for the development and maintenance of squamous epithelia.
GPL570:
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
Citation:
Barbieri CE, Tang LJ, Brown KA, Pietenpol JA. Loss of p63 leads to increased cell migration and up-regulation of genes involved in invasion and metastasis. Cancer Res 2006 Aug 1;66(15):7589-97. PMID: 16885358
