GEO Logo
   NCBI > GEO > Accession DisplayHelp Not logged in | LoginHelp
GEO help: Mouse over screen elements for information.
Series GSE4975 Query DataSets for GSE4975
Status Public on Jun 06, 2006
Title Expression data from p63 siRNA in squamous cell lines
Organism Homo sapiens
Experiment type Expression profiling by array
Summary p63, a homologue of the tumor suppressor p53, is critical for the development and maintenance of squamous epithelia. p63 is specifically expressed in the basal layers of stratified epithelial tissues, and is considered to be a specific marker for cells of this type. The role of p63 in tumorigenesis remains poorly defined. Numerous studies have highlighted the oncogenic potential of the predominant p63 isoform, ΔNp63α; however, data suggests that other p63 proteins can act as tumor suppressors or alter the metastatic potential of tumors. ΔNp63α can act as a transcriptional repressor, but the link between the transcriptional functions of p63 and its biological role is still unclear. In this study, we used a loss-of-function approach to investigate the transcriptional programs controlled by p63.
Keywords: cell line panel
Overall design A panel of squamous cell lines, including transformed and non-transformed cells, were transfected with hygromycin selectable vectors encoding p63 siRNA or control, then were selected with Hygromycin B and harvested.
Contributor(s) Barbieri CE, Pietenpol JA
Citation(s) 16885358
Submission date Jun 05, 2006
Last update date Mar 25, 2019
Contact name Jennifer Pietenpol
Organization name Vanderbilt University Medical Center
Department Biochemistry
Lab 652 PRB
Street address 23rd Ave South at Pierce
City Nashville
State/province TN
ZIP/Postal code 37232
Country USA
Platforms (3)
GPL96 [HG-U133A] Affymetrix Human Genome U133A Array
GPL97 [HG-U133B] Affymetrix Human Genome U133B Array
GPL570 [HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
Samples (14)
GSM112317 HaCaT RG cells transfected with control vector 1
GSM112318 HaCaT RG cells transfected with p63 siRNA 1
GSM112319 HaCaT RG cells transfected with control vector 2
BioProject PRJNA95479

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary data files not provided

| NLM | NIH | GEO Help | Disclaimer | Accessibility |
NCBI Home NCBI Search NCBI SiteMap