DataSet Record GDS1647: Expression Profiles Data Analysis Tools Sample Subsets
Title: RPE65 null mutant model of Leber's congenital amaurosis
Cluster AnalysisGDS1647 Cluster Image
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Summary: Analysis of retinas of RPE65 null mutants at 2, 4 and 6 months of age. RPE65 is highly expressed in retinal pigment epithelial cells. Mutations in REP65 cause 10-15% of Leber's congenital amaurosis (LCA) cases, a severe form of retinal dystrophy. Results provide insight into early LCA progression.
Organism: Mus musculus
Platform: GPL1261: [Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array
Citation:
  • Cottet S, Michaut L, Boisset G, Schlecht U et al. Biological characterization of gene response in Rpe65-/- mouse model of Leber's congenital amaurosis during progression of the disease. FASEB J 2006 Oct;20(12):2036-49. PMID: 17012256
Reference Series: GSE3249 Sample count: 18
Value type: transformed count Series published: 2006/02/01