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Series GSE3249 Query DataSets for GSE3249
Status Public on Feb 01, 2006
Title Analysis of RPE65 loss of function in mouse retina
Organism Mus musculus
Experiment type Expression profiling by array
Summary To characterize gene response in RPE65-/- mouse model of Leber’s congenital amaurosis during progression of the disease, we analyzed differential gene expression in retinae early in the development of the disease, namely before and at the onset of photoreceptor cell death in knock-out mice of 2, 4 and 6 months of age.
Keywords: knock out response over time
 
Overall design We compared gene expression in wild type and RPE65-/- retinae at 2, 4 and 6 months of age. Three biological replicates were performed for each of the six conditions analyzed; this series hence contains 18 samples.
 
Contributor(s) Michaut L, Cottet S, Gehring WJ, Schorderet D
Citation(s) 17012256
Submission date Sep 05, 2005
Last update date Feb 11, 2019
Contact name Lydia Michaut
E-mail(s) Lydia.Michaut@unibas.ch
Organization name Biozentrum, Basel University
Street address Klingelbergstrasse 70
City Basel
ZIP/Postal code 4056
Country Switzerland
 
Platforms (1)
GPL1261 [Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array
Samples (18)
GSM70899 RPE65_KO_2months_retina1
GSM70900 RPE65_KO_2months_retina2
GSM70901 RPE65_KO_2months_retina3
Relations
BioProject PRJNA92895

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