Anlaysis of alveolar macrophages of 5 phenotypically normal smokers who consume ~20 packs cigarettes/year. Smoking is the leading cause of respiratory diseases collectively known as chronic obstructive pulmonary disease (COPD). Provides insight into early events in molecular pathogenesis of COPD.
GPL80:
[Hu6800] Affymetrix Human Full Length HuGeneFL Array
Citation:
Heguy A, O'Connor TP, Luettich K, Worgall S et al. Gene expression profiling of human alveolar macrophages of phenotypically normal smokers and nonsmokers reveals a previously unrecognized subset of genes modulated by cigarette smoking. J Mol Med (Berl) 2006 Apr;84(4):318-28. PMID: 16520944
