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endonuclease/exonuclease/phosphatase family protein
This large family of proteins includes magnesium dependent endonucleases and a large number of phosphatases involved in intracellular signalling [1]. This family includes: AP endonuclease proteins EC:4.2.99.18 e.g Swiss:P27695, DNase I proteins EC:3.1.21.1 e.g. Swiss:P24855, Synaptojanin an inositol-1,4,5-trisphosphate phosphatase EC:3.1.3.56 Swiss:O43426, Sphingomyelinase EC:3.1.4.12 Swiss:P11889 and Nocturnin Swiss:O35710. [1]. 10838565. Functionally unrelated signalling proteins contain a fold. similar to Mg2+-dependent endonucleases.. Dlakic M;. Trends Biochem Sci 2000;25:272-273.. [2]. 7885481. Structure and function of the multifunctional DNA-repair enzyme. exonuclease III.. Mol CD, Kuo CF, Thayer MM, Cunningham RP, Tainer JA;. Nature 1995;374:381-386.. [3]. 1748997. DNase I-induced DNA conformation. 2 A structure of a DNase. I-octamer complex.. Lahm A, Suck D;. J Mol Biol 1991;222:645-667. (from Pfam)
ExeM/NucH family extracellular endonuclease
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