Protein Family Models

This entry contains members such as the arylmalonate decarboxylases (AMDase; EC 4.1.1.76), which belong to the family of carboxy-lyases (EC 4.1). Amdases are capable of decarboxylating a range of alpha-disubstituted malonic acid derivates to enantiopure products without the need for any cofactor. AMDases are members of the widespread Asp/Glu racemase family Pfam:PF01177 together with aspartate (EC 5.1.1.13) and glutamate racemases (EC 5.1.1.3), hydantoin racemases (EC 5.1.99.5) and maleate isomerases (EC 5.2.1.1) [1]. [1]. 27610105. Sequence-Based Screening for Rare Enzymes: New Insights into the. World of AMDases Reveal a Conserved Motif and 58 Novel Enzymes. Clustering in Eight Distinct Families.. Maimanakos J, Chow J, Gassmeyer SK, Gullert S, Busch F, Kourist. R, Streit WR;. Front Microbiol. 2016;7:1332. (from Pfam)

Date:

2024-08-14

This family contains aspartate racemase, maleate isomerases EC:5.2.1.1 [1], glutamate racemase, hydantoin racemase and arylmalonate decarboxylase EC:4.1.1.76 [2]. [1]. 20677745. A Covalent Succinylcysteine-like Intermediate in the. Enzyme-Catalyzed Transformation of Maleate to Fumarate by. Maleate Isomerase.. Fisch F, Fleites CM, Delenne M, Baudendistel N, Hauer B,. Turkenburg JP, Hart S, Bruce NC, Grogan G;. J Am Chem Soc. 2010;132:11455-11457.. [2]. 18576402. Structure and mechanism of an unusual malonate decarboxylase and. related racemases.. Okrasa K, Levy C, Hauer B, Baudendistel N, Leys D, Micklefield. J;. Chemistry. 2008;14:6609-6613. (from Pfam)

Date:

2024-08-14

COG3473 family protein

Date:

2017-03-02