Protein Family Models for Protein (Select 915796352) - Protein Family Models

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Select item 4169521.

Acetohydroxy acid isomeroreductase, NADPH-binding domain

Acetohydroxy acid isomeroreductase catalyses the conversion of acetohydroxy acids into dihydroxy valerates. This reaction is the second in the synthetic pathway of the essential branched side chain amino acids valine and isoleucine. This N-terminal region of the enzyme carries the binding-site for NADPH. The active-site for enzymatic activity lies in the C-terminal part, IlvC, Pfam:PF01450. [1]. 9218783. The crystal structure of plant acetohydroxy acid. isomeroreductase complexed with NADPH, two magnesium ions and a. herbicidal transition state analog determined at 1.65 A. resolution.. Biou V, Dumas R, Cohen-Addad C, Douce R, Job D, Pebay-Peyroula. E;. EMBO J 1997;16:3405-3415.. [2]. 16322583. The crystal structure of a bacterial class II ketol-acid. reductoisomerase: domain conservation and evolution.. Tyagi R, Duquerroy S, Navaza J, Guddat LW, Duggleby RG;. Protein Sci. 2005;14:3089-3100.. [3]. 19362563. Conformational changes in a plant ketol-acid reductoisomerase. upon Mg(2+) and NADPH binding as revealed by two crystal. structures.. Leung EW, Guddat LW;. J Mol Biol. 2009;389:167-182. (from Pfam)

Date:: 2024-08-14

Family Accession:: NF019603.5
Method:: HMM

Select item 4154072.

NAD(P)-binding domain-containing protein

Date:: 2024-08-14

Family Accession:: NF015747.5
Method:: HMM

Select item 4143543.

NAD(P)-binding domain-containing protein

The NAD binding domain of 6-phosphogluconate dehydrogenase adopts a Rossmann fold. (from Pfam)

GO Terms:

Molecular Function:: NADP binding (GO:0050661)

Date:: 2024-08-14

Family Accession:: NF015411.5
Method:: HMM

Select item 4132564.

NAD(P)-dependent oxidoreductase

This domain is inserted into the catalytic domain, the large dehydrogenase and D-lactate dehydrogenase families in SCOP. N-terminal portion of which is represented by family Pfam:PF00389. [1]. 9126843. Crystal structure of a ternary complex of D-2-hydroxyisocaproate. dehydrogenase from Lactobacillus casei, NAD+ and. 2-oxoisocaproate at 1.9 A resolution.. Dengler U, Niefind K, Kiess M, Schomburg D;. J Mol Biol 1997;267:640-660. (from Pfam)

GO Terms:

Molecular Function:: NAD binding (GO:0051287)

Date:: 2024-08-14

Family Accession:: NF014841.5
Method:: HMM

Select item 4126635.

2-dehydropantoate 2-reductase N-terminal domain-containing protein

This is a family of 2-dehydropantoate 2-reductases also known as ketopantoate reductases, EC:1.1.1.169. The reaction catalysed by this enzyme is: (R)-pantoate + NADP(+) <=> 2-dehydropantoate + NADPH. AbpA catalyses the NADPH reduction of ketopantoic acid to pantoic acid in the alternative pyrimidine biosynthetic (APB) pathway [2]. ApbA and PanE are allelic [2]. ApbA, the ketopantoate reductase enzyme is required for the synthesis of thiamine via the APB biosynthetic pathway [1]. [1]. 9488683. ApbA, the ketopantoate reductase enzyme of Salmonella. typhimurium is required for the synthesis of thiamine via the. alternative pyrimidine biosynthetic pathway.. Frodyma ME, Downs D;. J Biol Chem 1998;273:5572-5576.. [2]. 9721324. The panE gene, encoding ketopantoate reductase, maps at 10. minutes and is allelic to apbA in Salmonella typhimurium.. Frodyma ME, Downs D;. J Bacteriol 1998;180:4757-4759. (from Pfam)

Date:: 2024-08-14

Family Accession:: NF014601.5
Method:: HMM

Select item 4115566.

Acetohydroxy acid isomeroreductase, catalytic domain

Acetohydroxy acid isomeroreductase catalyses the conversion of acetohydroxy acids into dihydroxy valerates. This reaction is the second in the synthetic pathway of the essential branched side chain amino acids valine and isoleucine. [1]. 9218783. The crystal structure of plant acetohydroxy acid. isomeroreductase complexed with NADPH, two magnesium ions and a. herbicidal transition state analog determined at 1.65 A. resolution.. Biou V, Dumas R, Cohen-Addad C, Douce R, Job D, Pebay-Peyroula. E;. EMBO J 1997;16:3405-3415. (from Pfam)

GO Terms:

Molecular Function:: ketol-acid reductoisomerase activity (GO:0004455)

Biological Process:: branched-chain amino acid biosynthetic process (GO:0009082)

Date:: 2024-08-14

Family Accession:: NF013606.5
Method:: HMM

Select item 3957717.