Protein Family Models for Protein (Select 763213293) - Protein Family Models

Select item 4173281.

This HMM hits multiple proteins of peptidoglycan (murein) biosynthesis, such as MurC, MurD, MurE, and MurF of Escherichia coli.

GO Terms:

Molecular Function:: ATP binding (GO:0005524)

Biological Process:: biosynthetic process (GO:0009058)

Molecular Function:: acid-amino acid ligase activity (GO:0016881)

Date:: 2024-08-14

Family Accession:: NF019850.5
Method:: HMM

Select item 4136942.

glutamate ligase domain-containing protein

This family contains a number of related ligase enzymes which have EC numbers 6.3.2.*. This family includes: MurC (Swiss:P17952), MurD (Swiss:P14900), MurE (Swiss:P22188), MurF (Swiss:P11880), Mpl (Swiss:P37773) and FolC (Swiss:P08192). MurC, MurD, Mure and MurF catalyse consecutive steps in the synthesis of peptidoglycan. Peptidoglycan consists of a sheet of two sugar derivatives, with one of these N-acetylmuramic acid attaching to a small pentapeptide. The pentapeptide is is made of L-alanine, D-glutamic acid, Meso-diaminopimelic acid and D-alanyl alanine. The peptide moiety is synthesised by successively adding these amino acids to UDP-N-acetylmuramic acid. MurC transfers the L-alanine, MurD transfers the D-glutamate, MurE transfers the diaminopimelic acid, and MurF transfers the D-alanyl alanine. This family also includes Folylpolyglutamate synthase that transfers glutamate to folylpolyglutamate. [1]. 9218784. Crystal structure of UDP-N-acetylmuramoyl-L-alanine:D-glutamate. ligase from Escherichia coli.. Bertrand JA, Auger G, Fanchon E, Martin L, Blanot D, van. Heijenoort J, Dideberg O;. EMBO J 1997;16:3416-3425. (from Pfam)

GO Terms:

Biological Process:: biosynthetic process (GO:0009058)

Molecular Function:: acid-amino acid ligase activity (GO:0016881)

Date:: 2024-08-14

Family Accession:: NF014874.5
Method:: HMM

Select item 3947243.

new record, indexing in progress

Family Accession:

Select item 3904304.

new record, indexing in progress

Family Accession:

Select item 3535785.

new record, indexing in progress

Family Accession:

Select item 518556.

Mur ligase family protein

Mur ligase family protein similar to UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase (MurD) and UDP-N-acetylmuramoyl-L-alanine--L-glutamate ligase (MurD2), which catalyze the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)

Date:: 2024-04-24

Family Accession:: 11433699
Method:: Sparcle

Select item 260617.

UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase

Involved in peptidoglycan biosynthesis; catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine during cell wall formation

Gene:: murD

GO Terms:

Molecular Function:: ATP binding (GO:0005524)

Cellular Component:: cytoplasm (GO:0005737)

Biological Process:: regulation of cell shape (GO:0008360)

Molecular Function:: UDP-N-acetylmuramoylalanine-D-glutamate ligase activity (GO:0008764)

Biological Process:: peptidoglycan biosynthetic process (GO:0009252)

Biological Process:: cell division (GO:0051301)

Date:: 2024-05-30

Family Accession:: TIGR01087.1
Method:: HMM

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