Protein Family Models

This family includes CobD proteins from a number of bacteria, in Salmonella this protein is called Cbib. Salmonella CobD is a different protein [1]. This protein is involved in cobalamin biosynthesis and is probably an enzyme responsible for the conversion of adenosylcobyric acid to adenosylcobinamide or adenosylcobinamide phosphate [1]. [1]. 7635831. Identification and sequence analysis of genes involved in late. steps in cobalamin (vitamin B12) synthesis in Rhodobacter. capsulatus.. Pollich M, Klug G;. J Bacteriol 1995;177:4481-4487.. See figure 6 for proposed reaction of this enzyme.. [2]. 9446573. CobD, a novel enzyme with L-threonine-O-3-phosphate. decarboxylase activity, is responsible for the synthesis of. (R)-1-amino-2-propanol O-2-phosphate, a proposed new. intermediate in cobalamin biosynthesis in Salmonella typhimurium. LT2.. Brushaber KR, O'Toole GA, Escalante-Semerena JC;. J Biol Chem 1998;273:2684-2691. (from Pfam)

Date:

2024-08-14

CobD/CbiB family cobalamin biosynthesis protein converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group; similar to cobalamin biosynthesis protein CobD

Date:

2023-01-05

CbiB is adenosylcobinamide-phosphate synthase. It is part of the anaerobic cobalamin biosynthesis pathway, as found in Salmonella enterica. The name CobD had been associated with this family in other contexts, but that name now belongs more properly to threonine-phosphate decarboxylase (see model TIGR01140).

Gene:

cbiB

Date:

2024-06-14