Protein Family Models for Protein (Select 728042981) - Protein Family Models

Select item 4114011.

Na/H antiporters are key transporters in maintaining the pH of actively metabolising cells. The molecular mechanisms of antiport are unclear. These antiporters contain 10-12 transmembrane regions (M) at the amino-terminus and a large cytoplasmic region at the carboxyl terminus. The transmembrane regions M3-M12 share identity with other members of the family. The M6 and M7 regions are highly conserved. Thus, this is thought to be the region that is involved in the transport of sodium and hydrogen ions. The cytoplasmic region has little similarity throughout the family. [1]. 9537504. Comparative molecular analysis of Na+/H+ exchangers: a unified. model for Na+/H+ antiport?. Dibrov P, Fliegel L;. FEBS Lett 1998;424:1-5.. [2]. 9278382. Na+/H+ exchangers of mammalian cells.. Orlowski J, Grinstein S;. J Biol Chem 1997;272:22373-22376.. [3]. 9507001. Identification of a mitochondrial Na+/H+ exchanger.. Numata M, Petrecca K, Lake N, Orlowski J;. J Biol Chem 1998;273:6951-6959. (from Pfam)

GO Terms:

Biological Process:: monoatomic cation transport (GO:0006812)

Molecular Function:: antiporter activity (GO:0015297)

Cellular Component:: membrane (GO:0016020)

Biological Process:: transmembrane transport (GO:0055085)

Biological Process:: proton transmembrane transport (GO:1902600)

Date:: 2024-08-14

Family Accession:: NF013188.5
Method:: HMM

Select item 3894402.

new record, indexing in progress

Family Accession:

Select item 3465743.

new record, indexing in progress

Family Accession:

Select item 2270854.

potassium/proton antiporter

potassium/proton antiporter extrudes potassium in exchange for external protons and maintains the internal concentration of potassium under toxic levels

Date:: 2023-05-25

Family Accession:: 11480727
Method:: Sparcle

Select item 350755.

potassium/proton antiporter

Date:: 2020-10-26

Family Accession:: NF003715.0
Method:: HMM

Select item 343516.

potassium/proton antiporter

GO Terms:

Biological Process:: potassium ion transport (GO:0006813)

Molecular Function:: monoatomic cation transmembrane transporter activity (GO:0008324)

Cellular Component:: membrane (GO:0016020)

Date:: 2022-10-11

Family Accession:: NF003716.0
Method:: HMM

Select item 343507.

potassium/proton antiporter

GO Terms:

Biological Process:: potassium ion transport (GO:0006813)

Biological Process:: cell volume homeostasis (GO:0006884)

Cellular Component:: membrane (GO:0016020)

Molecular Function:: metal cation:proton antiporter activity (GO:0051139)

Biological Process:: transmembrane transport (GO:0055085)

Date:: 2022-12-21

Family Accession:: NF003714.0
Method:: HMM

Protein Family Models

Protein Family

Send to:

Links from Protein

Items: 7

Send to:

Supplemental Content

Find related data

Recent activity