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glutamate synthase central domain-containing protein
The central domain of glutamate synthase connects the amino terminal amidotransferase domain with the FMN-binding domain and has an alpha / beta overall topology [1]. This domain appears to be a rudimentary form of the FMN-binding TIM barrel according to SCOP. [1]. 11967268. Structural studies on the synchronization of catalytic centers. in glutamate synthase.. van den Heuvel RH, Ferrari D, Bossi RT, Ravasio S, Curti B,. Vanoni MA, Florencio FJ, Mattevi A;. J Biol Chem 2002;277:24579-24583. (from Pfam)
glutamate synthase-related protein
This family represents a region of the glutamate synthase protein. This region is expressed as a separate subunit in the glutamate synthase alpha subunit from archaebacteria, or part of a large multidomain enzyme in other organisms. The aligned region of these proteins contains a putative FMN binding site and Fe-S cluster. [1]. 8923741. Sequence of the GLT1 gene from Saccharomyces cerevisiae reveals. the domain structure of yeast glutamate synthase.. Filetici P, Martegani MP, Valenzuela L, Gonzalez A, Ballario P;. Yeast 1996;12:1359-1366. (from Pfam)
GXGXG motif
This domain is found in glutamate synthase, tungsten formylmethanofuran dehydrogenase subunit c (FwdC) and molybdenum formylmethanofuran dehydrogenase subunit c (FmdC). A repeated G-XX-G-XXX-G motif is seen in the alignment. [1]. 9818358. The formylmethanofuran dehydrogenase isoenzymes in. Methanobacterium wolfei and Methanobacterium. thermoautotrophicum: induction of the molybdenum isoenzyme by. molybdate and constitutive synthesis of the tungsten isoenzyme.. Hochheimer A, Hedderich R, Thauer RK;. Arch Microbiol 1998;170:389-393. (from Pfam)
Glutamine amidotransferases class-II
glutamate synthase large subunit
Catalyzes the formation of glutamate from glutamine and alpha-ketoglutarate
glutamate synthase large subunit is a component of a complex that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine
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