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endonuclease/exonuclease/phosphatase family protein
This large family of proteins includes magnesium dependent endonucleases and a large number of phosphatases involved in intracellular signalling [1]. This family includes: AP endonuclease proteins EC:4.2.99.18 e.g Swiss:P27695, DNase I proteins EC:3.1.21.1 e.g. Swiss:P24855, Synaptojanin an inositol-1,4,5-trisphosphate phosphatase EC:3.1.3.56 Swiss:O43426, Sphingomyelinase EC:3.1.4.12 Swiss:P11889 and Nocturnin Swiss:O35710. [1]. 10838565. Functionally unrelated signalling proteins contain a fold. similar to Mg2+-dependent endonucleases.. Dlakic M;. Trends Biochem Sci 2000;25:272-273.. [2]. 7885481. Structure and function of the multifunctional DNA-repair enzyme. exonuclease III.. Mol CD, Kuo CF, Thayer MM, Cunningham RP, Tainer JA;. Nature 1995;374:381-386.. [3]. 1748997. DNase I-induced DNA conformation. 2 A structure of a DNase. I-octamer complex.. Lahm A, Suck D;. J Mol Biol 1991;222:645-667. (from Pfam)
XthA family protein
exodeoxyribonuclease III
All proteins in this family for which functions are known are 5' AP endonucleases that function in base excision repair and the repair of abasic sites in DNA. Note that the member from Methanothermobacter thermautotrophicus functions additionally as a DNA uridine endonuclease. This family derived from the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).
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