Protein Family Models

This domain is found in polysaccharide deacetylase. This family of polysaccharide deacetylases includes NodB (nodulation protein B from Rhizobium) which is a chitooligosaccharide deacetylase [1]. It also includes chitin deacetylase from yeast [2], and endoxylanases which hydrolyses glucosidic bonds in xylan [3]. [1]. 9163424. Molecular basis of symbiosis between Rhizobium and legumes.. Freiberg C, Fellay R, Bairoch A, Broughton WJ, Rosenthal A,. Perret X;. Nature 1997;387:394-401.. [2]. 9133736. Cloning and expression of two chitin deacetylase genes of. Saccharomyces cerevisiae.. C. Mishra, C. E. Semino, K. J. McCreath, H. de la Vega, B. J.. Jones, C. A. Specht & P. W. Robbins;. Yeast 1996;13:327-336.. [3]. 8170399. Evidence for a general role for high-affinity non-catalytic. cellulose binding domains in microbial plant cell wall. hydrolases.. S. J. Millward-Sadler, D. M. Poole, B. Henrissat, G. P.. Hazlewood, J. H. Clarke & H. J. Gilbert;. Mol Microbiol 1994;11:375-382. (from Pfam)

Date:

2024-08-14

metal-dependent polysaccharide deacetylase family protein, belonging to the carbohydrate esterase 4 (CE4) superfamily, may catalyze the N- or O-deacetylation of a substrate such as acetylated chitin, peptidoglycan, and acetylated xylan

Date:

2017-03-02

Muramic delta-lactam is an unusual constituent of peptidoglycan, found only in bacterial spores in the peptidoglycan wall, or spore cortex. The proteins in this family are PdaA (yfjS), a member of a larger family of polysaccharide deacetylases, and are specificially involved in delta-lactam biosynthesis. PdaA acts immediately after CwlD, an N-acetylmuramoyl-L-alanine amidase and performs a de-N-acetylation. PdaA may also perform the following transpeptidation for lactam ring formation, as heterologous expression in E. coli of CwlD and PdaA together is sufficient for delta-lactam production.

Gene:

pdaA

Date:

2021-10-01