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Links from Protein

Items: 14

1.

ATP-binding protein

This family represents, additionally, the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90. [1]. 18361456. Crystal structure of a novel non-Pfam protein AF1514 from. Archeoglobus fulgidus DSM 4304 solved by S-SAD using a Cr X-ray. source.. Li Y, Bahti P, Shaw N, Song G, Chen S, Zhang X, Zhang M, Cheng. C, Yin J, Zhu JY, Zhang H, Che D, Xu H, Abbas A, Wang BC, Liu. ZJ;. Proteins 2008;71:2109-13. (from Pfam)

Date:
2024-08-14

Family Accession:
NF024977.5
Method:
HMM

2.

MutL C terminal dimerisation domain

MutL and MutS are key components of the DNA repair machinery that corrects replication errors [1]. MutS recognises mispaired or unpaired bases in a DNA duplex and in the presence of ATP, recruits MutL to form a DNA signaling complex for repair. The N terminal region of MutL contains the ATPase domain and the C terminal is involved in dimerisation [3]. [1]. 8811176. Mismatch repair in replication fidelity, genetic recombination,. and cancer biology.. Modrich P, Lahue R;. Annu Rev Biochem. 1996;65:101-133.. [2]. 16024043. Analysis of the quaternary structure of the MutL C-terminal. domain.. Kosinski J, Steindorf I, Bujnicki JM, Giron-Monzon L, Friedhoff. P;. J Mol Biol. 2005;351:895-909.. [3]. 15470502. Structure of the MutL C-terminal domain: a model of intact MutL. and its roles in mismatch repair.. Guarne A, Ramon-Maiques S, Wolff EM, Ghirlando R, Hu X, Miller. JH, Yang W;. EMBO J. 2004;23:4134-4145. (from Pfam)

GO Terms:
Molecular Function:
ATP binding (GO:0005524)
Biological Process:
mismatch repair (GO:0006298)
Date:
2024-08-14

Family Accession:
NF020260.5
Method:
HMM

3.

ATP-binding protein

This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90. [1]. 18361456. Crystal structure of a novel non-Pfam protein AF1514 from. Archeoglobus fulgidus DSM 4304 solved by S-SAD using a Cr X-ray. source.. Li Y, Bahti P, Shaw N, Song G, Chen S, Zhang X, Zhang M, Cheng. C, Yin J, Zhu JY, Zhang H, Che D, Xu H, Abbas A, Wang BC, Liu. ZJ;. Proteins 2008;71:2109-13. (from Pfam)

Date:
2024-08-14

Family Accession:
NF014567.5
Method:
HMM

4.

DNA mismatch repair protein, C-terminal domain

This family represents the C-terminal domain of the mutL/hexB/PMS1 family. This domain has a ribosomal S5 domain 2-like fold. (from Pfam)

GO Terms:
Molecular Function:
ATP binding (GO:0005524)
Biological Process:
mismatch repair (GO:0006298)
Molecular Function:
mismatched DNA binding (GO:0030983)
Date:
2024-08-14

Family Accession:
NF013299.5
Method:
HMM

5.
new record, indexing in progress
Family Accession:
6.
new record, indexing in progress
Family Accession:
7.
new record, indexing in progress
Family Accession:
8.
new record, indexing in progress
Family Accession:
9.
new record, indexing in progress
Family Accession:
10.
new record, indexing in progress
Family Accession:
11.
new record, indexing in progress
Family Accession:
12.
new record, indexing in progress
Family Accession:
13.

DNA mismatch repair endonuclease MutL

All proteins in this family for which the functions are known are involved in the process of generalized mismatch repair. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).

Gene:
mutL
GO Terms:
Molecular Function:
ATP binding (GO:0005524)
Biological Process:
mismatch repair (GO:0006298)
Molecular Function:
ATP hydrolysis activity (GO:0016887)
Molecular Function:
mismatched DNA binding (GO:0030983)
Date:
2024-05-30

Family Accession:
TIGR00585.2
Method:
HMM

14.
new record, indexing in progress
Family Accession:
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