Protein Family Models for Protein (Select 516539271) - Protein Family Models

Select item 4140411.

ATP cone domain-containing protein

Date:: 2024-08-14

Family Accession:: NF015442.5
Method:: HMM

Select item 4133662.

Ribonucleotide reductase, barrel domain

GO Terms:

Biological Process:: DNA replication (GO:0006260)

Date:: 2024-08-14

Family Accession:: NF014868.5
Method:: HMM

Select item 4116383.

ribonucleotide reductase N-terminal alpha domain-containing protein

GO Terms:

Molecular Function:: ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor (GO:0004748)

Molecular Function:: ATP binding (GO:0005524)

Biological Process:: DNA replication (GO:0006260)

Date:: 2024-08-14

Family Accession:: NF012537.5
Method:: HMM

Select item 3932994.

new record, indexing in progress

Family Accession:

Select item 3911175.

new record, indexing in progress

Family Accession:

Select item 3893226.

new record, indexing in progress

Family Accession:

Select item 3507297.

new record, indexing in progress

Family Accession:

Select item 3494508.

new record, indexing in progress

Family Accession:

Select item 3467499.

new record, indexing in progress

Family Accession:

Select item 16221310.

ribonucleoside-diphosphate reductase subunit alpha

GO Terms:

Molecular Function:: ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor (GO:0004748)

Molecular Function:: ATP binding (GO:0005524)

Biological Process:: DNA replication (GO:0006260)

Date:: 2021-08-24

Family Accession:: NF005544.0
Method:: HMM

Select item 12313511.

ribonucleoside-diphosphate reductase subunit alpha

ribonucleoside-diphosphate reductase subunit alpha catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides

Date:: 2019-03-18

Family Accession:: 11482630
Method:: Sparcle

Select item 4930812.

ribonucleoside-diphosphate reductase subunit alpha

This model represents the alpha (large) chain of the class I ribonucleotide reductase (RNR). RNR's are responsible for the conversion of the ribose sugar of RNA into the deoxyribose sugar of DNA. This is the rate-limiting step of DNA biosynthesis. Class I RNR's generate the required radical (on tyrosine) via a "non-heme" iron cofactor which resides in the beta (small) subunit. The alpha subunit contains the catalytic and allosteric regulatory sites. The mechanism of this enzyme requires molecular oxygen [1]. E. Coli contains two versions of this enzyme which are regulated independently (NrdAB and NrdEF, where NrdA and NrdE are the large chains [2,3]). Most organisms contain only one, but the application of the gene symbols NrdA and NrdE are somewhat arbitrary. This model identifies RNR's in diverse clades of bacteria, eukaryotes as well as numerous DNA viruses and phage.

GO Terms:

Molecular Function:: ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor (GO:0004748)

Cellular Component:: ribonucleoside-diphosphate reductase complex (GO:0005971)

Biological Process:: 2'-deoxyribonucleotide biosynthetic process (GO:0009265)

Date:: 2021-05-12

Family Accession:: TIGR02506.1
Method:: HMM

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