Protein Family Models

This P-loop motif-containing family of proteins includes AFG1, LACE1 and ZapE. ATPase family gene 1 (AFG1) is a 377 amino acid yeast protein with an ATPase motif typical of the family [1]. LACE1, the mammalian homologue of AFG1, is a mitochondrial integral membrane protein that is essential for maintenance of fused mitochondrial reticulum and lamellar cristae morphology. It has also been demonstrated that LACE1 mediates degradation of nuclear-encoded complex IV subunits COX4 (cytochrome c oxidase 4), COX5A and COX6A, and is required for normal activity of complexes III and IV of the respiratory chain [2]. ZapE is a cell division protein found in Gram-negative bacteria. The bacterial cell division process relies on the assembly, positioning, and constriction of FtsZ ring (the so-called Z-ring), a ring-like network that marks the future site of the septum of bacterial cell division. ZapE is a Z-ring associated protein required for cell division under low-oxygen conditions. It is an ATPase that appears at the constricting Z-ring late in cell division. It reduces the stability of FtsZ polymers in the presence of ATP in vitro [3]. [1]. 1441755. AFG1, a new member of the SEC18-NSF, PAS1, CDC48-VCP, TBP family. of ATPases.. Lee YJ, Wickner RB;. Yeast 1992;8:787-790.. [2]. 26759378. The mammalian homologue of yeast Afg1 ATPase (lactation elevated. 1) mediates degradation of nuclear-encoded complex IV subunits.. Cesnekova J, Rodinova M, Hansikova H, Houstek J, Zeman J,. Stiburek L;. Biochem J. 2016;473:797-804.. [3]. 24595368. ZapE is a novel cell division protein interacting with FtsZ and. modulating the Z-ring dynamics.. Martey. TRUNCATED at 1650 bytes (from Pfam)

Gene:

zapE

Date:

2024-08-14

The ATPase ZapE directly interacts with cell division protein FtsZ. It has been reported that ZapE destabilized FtsZ polymers in an ATP-dependent manner. In addition, ZapE is required for E. coli to grow under conditions of low oxygen, suggesting ZapE is a stress-regulated cell division protein.

Gene:

zapE

Date:

2022-02-18

AFG1/ZapE family ATPase similar to cell division protein ZapE, that interacts with FtsZ and modulates the Z-ring dynamics

Date:

2023-12-19