Protein Family Models

ABC transporters for a large family of proteins responsible for translocation of a variety of compounds across biological membranes. ABC transporters are the largest family of proteins in many completely sequenced bacteria. ABC transporters are composed of two copies of this domain and two copies of a transmembrane domain Pfam:PF00664. These four domains may belong to a single polypeptide as in Swiss:P13569, or belong in different polypeptide chains. [1]. 1864505. Homology between proteins controlling Streptomyces fradiae. tylosin resistance and ATP-binding transport.. Rosteck PR Jr, Reynolds PA, Hershberger CL;. Gene 1991;102:27-32.. [2]. 1977073. Structure and function of haemolysin B,P-glycoprotein and other. members of a novel family of membrane translocators.. Blight MA, Holland IB;. Mol Microbiol 1990;4:873-880.. [3]. 2229036. Binding protein-dependent transport systems.. Higgins CF, Hyde SC, Mimmack MM, Gileadi U, Gill DR, Gallagher. MP;. J Bioenerg Biomembr 1990;22:571-592.. [4]. 9872322. Crystal structure of the ATP-binding subunit of an ABC. transporter.. Hung LW, Wang IX, Nikaido K, Liu PQ, Ames GF, Kim SH;. Nature 1998;396:703-707. (from Pfam)

Date:

2024-08-14

cell division ATP-binding protein FtsE is part of the ABC transporter FtsEX involved in cellular division or sporulation, which controls periplasmic peptidoglycan (PG) hydrolase activities in many Gram negative and positive organisms to enable separation of daughter cells during division

Date:

2023-02-14

This model describes FtsE, a member of the ABC transporter ATP-binding protein family. This protein, and its permease-like partner FtsX, localize to the division site and are considered part of the divisome. The current understanding of FtsEX function is that is does not perform transport, but instead mechanically transmits a signal from cytosol to periplasm in order to activate lytic enzymes there.

Gene:

ftsE

Date:

2023-04-21