Protein Family Models for Protein (Select 504152279) - Protein Family Models

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Items: 4

Select item 4134411.

TolC family protein

The OEP family (Outer membrane efflux protein) form trimeric channels that allow export of a variety of substrates in Gram negative bacteria. Each member of this family is composed of two repeats. The trimeric channel is composed of a 12 stranded all beta sheet barrel that spans the outer membrane, and a long all helical barrel that spans the periplasm. [1]. 10092468. Alignment and structure prediction of divergent protein. families: periplasmic and outer membrane proteins of bacterial. efflux pumps.. Johnson JM, Church GM;. J Mol Biol 1999;287:695-715. (from Pfam)

GO Terms:

Molecular Function:: efflux transmembrane transporter activity (GO:0015562)

Biological Process:: transmembrane transport (GO:0055085)

Date:: 2024-08-14

Family Accession:: NF014385.5
Method:: HMM

Select item 3902632.

new record, indexing in progress

Family Accession:

Select item 3482323.

new record, indexing in progress

Family Accession:

Select item 1428494.

TolC family outer membrane protein

Members of this HMM are outer membrane proteins from the TolC subfamily within the RND (Resistance-Nodulation-cell Division) efflux systems. Members may participate in small molecule effux by RND-type transporters, type I protein secretion systems (T1SS, an ABC transporter system for protein secretion without cleavage of a signal sequence), or both. This family includes T1SS examples TolC (E. coli), PrtF (Erwinia), and AprF (Pseudomonas aeruginosa), as well as efflux proteins BepC, OpmH, etc.

GO Terms: