Warning: The NCBI web site requires JavaScript to function. more...
An official website of the United States government
The .gov means it's official. Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.
The site is secure. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.
nucleotidyltransferase domain-containing protein
This family is conserved in Bacteria. It confers resistance to kanamycin, gentamicin, and tobramycin [1]. The protein is also produced by plasmids in various bacterial species and confers resistance to essentially all clinically available aminoglycosides except streptomycin, and it eliminates the synergism between aminoglycosides and cell-wall active agents [2]. [1]. 3024112. Nucleotide sequence of the AAD(2'') aminoglycoside. adenylyltransferase determinant aadB. Evolutionary relationship. of this region with those surrounding aadA in R538-1 and dhfrII. in R388.. Cameron FH, Groot Obbink DJ, Ackerman VP, Hall RM;. Nucleic Acids Res. 1986;14:8625-8635.. [2]. 17030911. Insertion sequence ISEcp1-like element connected with a novel. aph(2'') allele [aph(2'')-Ie] conferring high-level gentamicin. resistance and a novel streptomycin adenylyltransferase gene in. Enterococcus.. Chen YG, Qu TT, Yu YS, Zhou JY, Li LJ;. J Med Microbiol. 2006;55:1521-1525. (from Pfam)
Filter your results:
Your browsing activity is empty.
Activity recording is turned off.
Turn recording back on