Protein Family Models for Protein (Select 503318543) - Protein Family Models

Select item 4119151.

aconitase family protein

Members of this family include aconitase (aconitate hydratase), 3-isopropylmalate dehydratase, and homoaconitase.

Date:: 2024-08-14

Family Accession:: NF012550.5
Method:: HMM

Select item 3888312.

new record, indexing in progress

Family Accession:

Select item 3469643.

new record, indexing in progress

Family Accession:

Select item 3362864.

aconitase/3-isopropylmalate dehydratase large subunit family protein

Date:: 2022-02-11

Family Accession:: NF001614.1
Method:: HMM

Select item 2515645.

3-isopropylmalate dehydratase large subunit

3-isopropylmalate dehydratase large subunit catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate

Date:: 2017-03-23

Family Accession:: 10011418
Method:: Sparcle

Select item 1430736.

3-isopropylmalate dehydratase/homoaconitate hydratase family large subunit

This subfamily is a subset of the larger HacA family (homoaconitate hydratase family, TIGR01343). Many members of this subfamily are archaeal examples of the 3-isopropylmalate dehydratase large subunit, but the family includes additional paralogs that may differ in function as well as proteins characterized as multifunctional.

GO Terms:

Molecular Function:: 3-isopropylmalate dehydratase activity (GO:0003861)

Biological Process:: L-leucine biosynthetic process (GO:0009098)

Molecular Function:: 4 iron, 4 sulfur cluster binding (GO:0051539)

Date:: 2024-05-30

Family Accession:: TIGR02086.1
Method:: HMM

Select item 1429647.

3-isopropylmalate dehydratase large subunit

Homoaconitase, aconitase, and 3-isopropylmalate dehydratase have similar overall structures. All are dehydratases (EC 4.2.1.-) and bind a Fe-4S iron-sulfur cluster. 3-isopropylmalate dehydratase is split into large (leuC) and small (leuD) chains in eubacteria. Several pairs of archaeal proteins resemble the leuC and leuD pair in length and sequence but even more closely resemble the respective domains of homoaconitase, and their identity is uncertain. These homologs are described by a separate model of subfamily (rather than equivalog) homology type (TIGR01343). This model along with TIGR00170 describe clades which consist only of LeuC sequences. Here, the genes from Pyrococcus furiosus, Clostridium acetobutylicum, Thermotoga maritima and others are gene clustered with related genes from the leucine biosynthesis pathway.

Gene:: leuC

GO Terms:

Molecular Function:: 3-isopropylmalate dehydratase activity (GO:0003861)

Biological Process:: L-leucine biosynthetic process (GO:0009098)

Cellular Component:: 3-isopropylmalate dehydratase complex (GO:0009316)

Molecular Function:: 4 iron, 4 sulfur cluster binding (GO:0051539)

Date:: 2024-06-27

Family Accession:: TIGR02083.1
Method:: HMM

Select item 1415408.

homoaconitate hydratase family protein

This HMM represents a subfamily of proteins consisting of aconitase, homoaconitase, 3-isopropylmalate dehydratase, and uncharacterized proteins. The majority of the members of this family have been designated as 3-isopropylmalate dehydratase large subunit (LeuC) in microbial genome annotation, but the only characterized member is Thermus thermophilus homoaconitase, an enzyme of a non-aspartate pathway of Lys biosynthesis.

GO Terms:

Biological Process:: amino acid biosynthetic process (GO:0008652)

Molecular Function:: hydro-lyase activity (GO:0016836)

Molecular Function:: 4 iron, 4 sulfur cluster binding (GO:0051539)

Date:: 2024-05-30

Family Accession:: TIGR01343.1
Method:: HMM

Select item 220399.

new record, indexing in progress

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