Protein Family Models for Protein (Select 503006918) - Protein Family Models

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Items: 4

Select item 4130861.

proteasome accessory factor PafA2 family protein

Pupylation is a novel protein modification system found in some bacteria [1]. This family of proteins are the enzyme that can conjugate proteins of the Pup family to lysine residues in target proteins marking them for degradation. The archetypal protein in this family is PafA (proteasome accessory factor) from Mycobacterium tuberculosis [2]. It has been suggested that these proteins are related to gamma-glutamyl-cysteine synthetases [1]. [1]. 18980670. Unraveling the biochemistry and provenance of pupylation: a. prokaryotic analog of ubiquitination.. Iyer LM, Burroughs AM, Aravind L;. Biol Direct. 2008;3:45.. [2]. 18832610. Ubiquitin-like protein involved in the proteasome pathway of. Mycobacterium tuberculosis.. Pearce MJ, Mintseris J, Ferreyra J, Gygi SP, Darwin KH;. Science. 2008;322:1104-1107. (from Pfam)

GO Terms:

Biological Process:: proteasomal protein catabolic process (GO:0010498)

Biological Process:: modification-dependent protein catabolic process (GO:0019941)

Date:: 2024-08-14

Family Accession:: NF015119.5
Method:: HMM

Select item 3910882.

new record, indexing in progress

Family Accession:

Select item 3493393.

new record, indexing in progress

Family Accession:

Select item 1474634.

depupylase/deamidase Dop

Dop (deamidase of Pup), originally called PafA2, is homologous to the Pup ligase PafA (proteasome accessory factor), but functions as a depupylase. Members of both this family and TIGR03686 itself tend to cluster with each other, with the ubiquitin analog Pup (TIGR03687) associated with targeting to the proteasome, and with proteasome subunits themselves.