Protein Family Models for Protein (Select 502732619) - Protein Family Models

Select item 4122331.

This enzyme catalyses the second step in the histidine biosynthetic pathway. [1]. 379004. The product of the his4 gene cluster in Saccharomyces. cerevisiae. A trifunctional polypeptide.. Keesey JK Jr, Bigelis R, Fink GR;. J Biol Chem 1979;254:7427-7433.. [2]. 3528746. Primary and secondary structural homologies between the HIS4. gene product of Saccharomyces cerevisiae and the hisIE and hisD. gene products of Escherichia coli and Salmonella typhimurium.. Bruni CB, Carlomagno MS, Formisano S, Paolella G;. Mol Gen Genet 1986;203:389-396. (from Pfam)

Date:: 2024-08-14

Family Accession:: NF013654.5
Method:: HMM

Select item 4121262.

phosphoribosyl-AMP cyclohydrolase

This enzyme catalyses the third step in the histidine biosynthetic pathway. It requires Zn ions for activity. [1]. 9931020. N1-(5'-phosphoribosyl)adenosine-5'-monophosphate cyclohydrolase:. purification and characterization of a unique metalloenzyme.. D'Ordine RL, Klem TJ, Davisson VJ;. Biochemistry 1999;38:1537-1546. (from Pfam)

GO Terms:

Biological Process:: L-histidine biosynthetic process (GO:0000105)

Molecular Function:: phosphoribosyl-AMP cyclohydrolase activity (GO:0004635)

Date:: 2024-08-14

Family Accession:: NF013653.5
Method:: HMM

Select item 3899223.

new record, indexing in progress

Family Accession:

Select item 3890134.

new record, indexing in progress

Family Accession:

Select item 3483725.

new record, indexing in progress

Family Accession:

Select item 3472326.

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Family Accession:

Select item 2269587.

bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase

bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase catalyzes the irreversible hydrolysis of phosphoribosyl-ATP (PRATP) to phosphoribosyl-AMP (PRAMP) and pyrophosphate, and the hydrolysis of the adenine ring of PRAMP, the second and third steps in histidine biosynthesis, respectively

Date:: 2023-03-07

Family Accession:: 11479841
Method:: Sparcle

Select item 528998.

phosphoribosyl-ATP diphosphatase

This enzyme, phosphoribosyl-ATP pyrophosphohydrolase, catalyses the second step in the histidine biosynthesis pathway. It often occurs as a fusion protein. This model a somewhat narrower scope than Pfam model PF01503, as some paralogs that appear to be functionally distinct are excluded from this model.

Gene:: hisE

GO Terms:

Biological Process:: L-histidine biosynthetic process (GO:0000105)

Molecular Function:: phosphoribosyl-ATP diphosphatase activity (GO:0004636)

Date:: 2021-04-27

Family Accession:: TIGR03188.1
Method:: HMM

Select item 281249.

bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE

Catalyzes the formation of 1-(5-phosphoribosyl)-AMP from 1-(5-phosphoribosyl)-ATP and the subsequent formation of 1-(5-phosphoribosyl)-5-((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide from 1-(5-phosphoribosyl)-AMP in histidine biosynthesis

Gene:: hisIE

GO Terms:

Biological Process:: L-histidine biosynthetic process (GO:0000105)

Molecular Function:: phosphoribosyl-AMP cyclohydrolase activity (GO:0004635)

Molecular Function:: phosphoribosyl-ATP diphosphatase activity (GO:0004636)

Date:: 2021-08-17

Family Accession:: NF002747.0
Method:: HMM

Select item 1616910.

phosphoribosyl-AMP cyclohydrolase

Functions in histidine biosynthesis from PRPP; converts 1-(5-phosphoribosyl)-AMP to 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxyamide during the histidine biosynthesis pathway; binds zinc and magnesium; forms homodimers

Gene:: hisI

GO Terms:

Biological Process:: L-histidine biosynthetic process (GO:0000105)

Molecular Function:: phosphoribosyl-AMP cyclohydrolase activity (GO:0004635)

Date:: 2021-07-23

Family Accession:: NF000768.0
Method:: HMM

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