Protein Family Models

This family is a member of the Alkaline phosphatase clan. (from Pfam)

Date:

2024-08-14

This family consists of phosphodiesterases, including human plasma-cell membrane glycoprotein PC-1 / alkaline phosphodiesterase i / nucleotide pyrophosphatase (nppase). These enzymes catalyse the cleavage of phosphodiester and phosphosulfate bonds in NAD, deoxynucleotides and nucleotide sugars [1]. Also in this family is ATX an autotaxin, tumour cell motility-stimulating protein which exhibits type I phosphodiesterases activity [4]. The alignment encompasses the active site [3,4]. Also present with in this family is 60-kDa Ca2+-ATPase form F. odoratum [2]. [1]. 9344668. Molecular cloning and chromosomal localization of PD-Ibeta. (PDNP3), a new member of the human phosphodiesterase I genes.. Jin-Hua P, Goding JW, Nakamura H, Sano K;. Genomics 1997;45:412-415.. [2]. 8617788. Cloning and expression of the unique Ca2+-ATPase from. Flavobacterium odoratum.. Peiffer WE, Desrosiers MG, Menick DR;. J Biol Chem 1996;271:5095-5100.. [3]. 7730366. Affinity purification and cDNA cloning of rat neural. differentiation and tumor cell surface antigen gp130RB13-6. reveals relationship to human and murine PC-1.. Deissler H, Lottspeich F, Rajewsky MF;. J Biol Chem 1995;270:9849-9855.. [4]. 7982964. cDNA cloning of the human tumor motility-stimulating protein,. autotaxin, reveals a homology with phosphodiesterases.. Murata J, Lee HY, Clair T, Krutzsch HC, Arestad AA, Sobel ME,. Liotta LA, Stracke ML;. J Biol Chem 1994;269:30479-30484. (from Pfam)

Date:

2024-08-14

Members of this family are uncharacterized proteins sporadically distributed in bacteria and archaea, about 880 amino acids in length. This protein is repeatedly found upstream of another uncharacterized protein of about 470 amino acids in length, modeled by TIGR02688.

Gene:

pglZ

Date:

2021-09-22