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dUTP diphosphatase
2-Deoxyuridine 5-triphosphate nucleotidohydrolase (dUTPase) catalyses the hydrolysis of dUTP to dUMP and pyrophosphate (EC:3.6.1.23). Members of this family have a novel all-alpha fold and are unrelated to the all-beta fold found in dUTPases of the majority of organisms [1]. This family contains both dUTPase homologues of dUTPase including dCTPase of phage T4. [1]. 15364583. The crystal structure of a complex of Campylobacter jejuni. dUTPase with substrate analogue sheds light on the mechanism and. suggests the "basic module" for dimeric d(C/U)TPases.. Moroz OV, Harkiolaki M, Galperin MY, Vagin AA,. Gonzalez-Pacanowska D, Wilson KS;. J Mol Biol. 2004;342:1583-1597. (from Pfam)
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