Protein Family Models

Members of this family act as antitoxins in type II toxin-antitoxin systems [1]. When bound to their toxin partners, they can bind DNA via the N-terminus and repress the expression of operons containing genes encoding the toxin and the antitoxin [2]. This domain complexes with Txe toxins containing Pfam:PF06769, Fic/DOC toxins containing Pfam:PF02661 and YafO toxins containing Pfam:PF13957. [1]. 14659018. New connections in the prokaryotic toxin-antitoxin network:. relationship with the eukaryotic nonsense-mediated RNA decay. system.. Anantharaman V, Aravind L;. Genome Biol 2003;4:R81.. [2]. 20603017. Allostery and intrinsic disorder mediate transcription. regulation by conditional cooperativity.. Garcia-Pino A, Balasubramanian S, Wyns L, Gazit E, De Greve H,. Magnuson RD, Charlier D, van Nuland NA, Loris R;. Cell. 2010;142:101-111. (from Pfam)

Date:

2024-08-14

type II toxin-antitoxin (TA) system Phd/YefM family antitoxin is the antitoxin component of a TA module that binds to its cognate toxin and neutralizes its mRNA interferase activity; similar to Escherichia virus P1 antitoxin phd (prevent-host-death)

Date:

2023-03-13

This HMM recognizes a region of about 55 amino acids toward the N-terminal end of bacterial proteins of about 85 amino acids in length. The best-characterized member is prevent-host-death (phd) of bacteriophage P1, the antidote partner of death-on-curing (doc) (TIGR01550) in an addiction module. Addiction modules prevent plasmid curing by killing the host cell as the longer-lived killing protein persists while the gene for the shorter-lived antidote is lost. Note, however, that relatively few members of this family appear to be plasmid or phage-encoded. Also, there is little overlap, except for phage P1 itself, of species with this family and with the doc family.

Date:

2021-04-27