Protein Family Models

The family consists of hydrogenase maturation proteases. In E. coli HypI the hydrogenase maturation protease is involved in processing of HypE the large subunit of hydrogenases 3, by cleavage of its C-terminal [1]. [1]. 7851435. Characterisation of a protease from Escherichia coli involved in. hydrogenase maturation.. Rossmann R, Maier T, Lottspeich F, Bock A;. Eur J Biochem 1995;227:545-550. (from Pfam)

Date:

2024-08-14

HyaD/HybD family hydrogenase maturation endopeptidase similar to Escherichia coli HybD that catalyzes the nickel-dependent cleavage of a short C-terminal peptide after a His or an Arg residue in the large subunit (pre-HybC) of hydrogenase 2

Date:

2017-03-02

FrhD is not part of the active FRH heterotrimer, but is probably a protease required for maturation. Alternative name: 8-hydroxy-5-deazaflavin (F420) reducing hydrogenase (FRH) subunit delta.

Gene:

frhD

Date:

2024-05-30

HycI and HoxM are well-characterized as responsible for C-terminal protease activity on their respective hydrogenase large chains. A large number of homologous proteins appear responsible for the maturation of various forms of hydrogenase.

Date:

2021-09-08