Protein Family Models

Members of this family include multiple membrane-spanning proteins associated with proton translocation. These include NADH ubiquinone oxidoreductase subunits NuoL, NuoN, and NuoM, hydrogenase components HyfB, HyfD, and HyfF, as well as subunits of carbon monoxide dehydrogenase, F420 dehydrogenase, etc, as well as Na+/H+ antiporter subunits.

Date:

2024-08-14

Gene:

nuoN

Date:

2023-12-18

This HMM describes the 14th (based on E. coli) structural gene, N, of bacterial and chloroplast energy-transducing NADH (or NADPH) dehydrogenases. This model does not describe any subunit of the mitochondrial complex I (for which the subunit composition is very different), nor NADH dehydrogenases that are not coupled to ion transport. For chloroplast members, the name NADH-plastoquinone oxidoreductase is used for the complex and this protein is designated as subunit 2 or B. This model also includes a subunit of a related complex in the archaeal methanogen, Methanosarcina mazei, in which F420H2 replaces NADH and 2-hydroxyphenazine replaces the quinone.

Gene:

nuoN

Date:

2024-05-30

NADH-quinone oxidoreductase subunit N (NuoN) is part of the membrane domain of the complex I of the respiratory chain that couples the transfer of electrons from NADH to quinone with the translocation of protons across the membrane

Date:

2024-09-11