Protein Family Models

RNA polymerases catalyse the DNA-dependent polymerisation of RNA. Prokaryotes contain a single RNA polymerase compared with three in eukaryotes (not including mitochondrial or chloroplast polymerases). This domain in prokaryotes spans the gap between domains 4 and 5 of the yeast protein. It is also known as the external 1 region of the polymerase and is bound in association with the external 2 region [1]. [1]. 11313498. Structural basis of transcription: RNA polymerase II at 2.8. angstrom resolution.. Cramer P, Bushnell DA, Kornberg RD;. Science 2001;292:1863-1876. (from Pfam)

Date:

2024-08-14

RNA polymerases catalyse the DNA dependent polymerisation of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Domain 3, s also known as the fork domain and is proximal to catalytic site [1]. [1]. 11313498. Structural basis of transcription: RNA polymerase II at 2.8. angstrom resolution.. Cramer P, Bushnell DA, Kornberg RD;. Science 2001;292:1863-1876. (from Pfam)

Date:

2024-08-14

RNA polymerases catalyse the DNA dependent polymerisation of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). This domain forms one of the two distinctive lobes of the Rpb2 structure. This domain is also known as the protrusion domain [1]. The other lobe (Pfam:PF04561) is nested within this domain. [1]. 3116266. RNA polymerase II of Drosophila. Relation of its 140,000 Mr. subunit to the beta subunit of Escherichia coli RNA polymerase.. Falkenburg D, Dworniczak B, Faust DM, Bautz EK;. J Mol Biol 1987;195:929-937.. [2]. 11313498. Structural basis of transcription: RNA polymerase II at 2.8. angstrom resolution.. Cramer P, Bushnell DA, Kornberg RD;. Science 2001;292:1863-1876. (from Pfam)

Date:

2024-08-14

RNA polymerases catalyse the DNA dependent polymerisation of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Rpb2 is the second largest subunit of the RNA polymerase. This domain forms one of the two distinctive lobes of the Rpb2 structure. This domain is also known as the lobe domain [1]. DNA has been demonstrated to bind to the concave surface of the lobe domain, and plays a role in maintaining the transcription bubble [1]. Many of the bacterial members contain large insertions within this domain, as region known as dispensable region 1 (DRI). [1]. 11313498. Structural basis of transcription: RNA polymerase II at 2.8. angstrom resolution.. Cramer P, Bushnell DA, Kornberg RD;. Science 2001;292:1863-1876. (from Pfam)

Date:

2024-08-14

RNA polymerases catalyse the DNA dependent polymerisation of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Rpb2 is the second largest subunit of the RNA polymerase. This domain comprised of the structural domains anchor and clamp [1]. The clamp region (C-terminal) contains a zinc-binding motif [1]. The clamp region is named due to its interaction with the clamp domain found in Rpb1. The domain also contains a region termed "switch 4". The switches within the polymerase are thought to signal different stages of transcription [1]. [1]. 11313498. Structural basis of transcription: RNA polymerase II at 2.8. angstrom resolution.. Cramer P, Bushnell DA, Kornberg RD;. Science 2001;292:1863-1876. (from Pfam)

Date:

2024-08-14

RNA polymerases catalyse the DNA dependent polymerisation of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). This domain represents the hybrid binding domain and the wall domain [1]. The hybrid binding domain binds the nascent RNA strand / template DNA strand in the Pol II transcription elongation complex. This domain contains the important structural motifs, switch 3 and the flap loop and binds an active site metal ion[1]. This domain is also involved in binding to Rpb1 and Rpb3 [1]. Many of the bacterial members contain large insertions within this domain, as region known as dispensable region 2 (DRII). [1]. 11313498. Structural basis of transcription: RNA polymerase II at 2.8. angstrom resolution.. Cramer P, Bushnell DA, Kornberg RD;. Science 2001;292:1863-1876. (from Pfam)

Date:

2024-08-14