Protein Family Models for Protein (Select 498480334) - Protein Family Models

Select item 4282821.

This domain is found at the C-terminal end of various glycosyl hydrolases belonging to family 38. The domain has a beta sandwich fold. [1]. 9649738. Glycosidase families. Henrissat B. Biochem Soc Trans 1998;26:153-156. (from Pfam)

Date:: 2024-08-14

Family Accession:: NF036773.5
Method:: HMM

Select item 4269282.

Glycosyl hydrolases family 38 C-terminal domain 1

The enzymatic hydrolysis of alpha-mannosides is catalyzed by glycoside hydrolases (GH), termed alpha-mannosidases. Streptococcal (Sp) GH38 alpha-mannosidase active on N-glycans and possibly O-glycans. SpGH38 structure can be considered as five domains: an N-terminal alpha/beta-domain, a three-helix bundle and three predominantly beta-sheet domains. This is the first of the three beta-sheet domains found in GH38, termed Beta-1. Structural analysis indicate that the beta-1 domain bows outward from the protein core, is involved in dimer interactions whilst also forming a lid 'above' and somewhat into the active centre of its dimer [1]. [1]. 20140249. Structure and kinetic investigation of Streptococcus pyogenes. family GH38 alpha-mannosidase.. Suits MD, Zhu Y, Taylor EJ, Walton J, Zechel DL, Gilbert HJ,. Davies GJ;. PLoS One. 2010;5:e9006. (from Pfam)

Date:: 2024-08-14

Family Accession:: NF037347.5
Method:: HMM

Select item 4214233.

Alpha mannosidase middle domain

Members of this family adopt a structure consisting of three alpha helices, in an immunoglobulin/albumin-binding domain-like fold. They are predominantly found in the enzyme alpha-mannosidase [1]. [1]. 12634058. The structure of bovine lysosomal alpha-mannosidase suggests a. novel mechanism for low-pH activation.. Heikinheimo P, Helland R, Leiros HK, Leiros I, Karlsen S, Evjen. G, Ravelli R, Schoehn G, Ruigrok R, Tollersrud OK, McSweeney S,. Hough E;. J Mol Biol. 2003;327:631-644. (from Pfam)

GO Terms:

Molecular Function:: alpha-mannosidase activity (GO:0004559)

Biological Process:: mannose metabolic process (GO:0006013)

Date:: 2024-08-14

Family Accession:: NF020822.5
Method:: HMM

Select item 4172164.

glycoside hydrolase family 38 C-terminal domain-containing protein

Glycosyl hydrolases are key enzymes of carbohydrate metabolism. [1]. 9649738. Glycosidase families. Henrissat B. Biochem Soc Trans 1998;26:153-156. (from Pfam)

GO Terms:

Molecular Function:: alpha-mannosidase activity (GO:0004559)

Biological Process:: mannose metabolic process (GO:0006013)

Date:: 2024-08-14

Family Accession:: NF019368.5
Method:: HMM

Select item 4117325.

Glycosyl hydrolases family 38 N-terminal domain

Glycosyl hydrolases are key enzymes of carbohydrate metabolism. [1]. 9649738. Glycosidase families. Henrissat B. Biochem Soc Trans 1998;26:153-156. (from Pfam)

GO Terms:

Molecular Function:: alpha-mannosidase activity (GO:0004559)

Biological Process:: mannose metabolic process (GO:0006013)

Date:: 2024-08-14

Family Accession:: NF013256.5
Method:: HMM

Select item 4059536.