Protein Family Models for Protein (Select 491946784) - Protein Family Models

Select item 4126031.

non-canonical purine NTP pyrophosphatase

This family consists of the HAM1 protein Swiss:P47119 and hypothetical archaeal bacterial and C. elegans proteins. HAM1 controls 6-N-hydroxylaminopurine (HAP) sensitivity and mutagenesis in S. cerevisiae Swiss:P47119 [1]. The HAM1 protein protects the cell from HAP, either on the level of deoxynucleoside triphosphate or the DNA level by a yet unidentified set of reactions [1]. [1]. 8789257. HAM1, the gene controlling 6-N-hydroxylaminopurine sensitivity. and mutagenesis in the yeast Saccharomyces cerevisiae.. Noskov VN, Staak K, Shcherbakova PV, Kozmin SG, Negishi K, Ono. BC, Hayatsu H, Pavlov YI;. Yeast 1996;12:17-29. (from Pfam)

GO Terms:

Biological Process:: nucleoside triphosphate catabolic process (GO:0009143)

Molecular Function:: nucleoside triphosphate diphosphatase activity (GO:0047429)

Date:: 2024-08-14

Family Accession:: NF013854.5
Method:: HMM

Select item 4115102.

aspartate/glutamate racemase family protein

This family contains aspartate racemase, maleate isomerases EC:5.2.1.1 [1], glutamate racemase, hydantoin racemase and arylmalonate decarboxylase EC:4.1.1.76 [2]. [1]. 20677745. A Covalent Succinylcysteine-like Intermediate in the. Enzyme-Catalyzed Transformation of Maleate to Fumarate by. Maleate Isomerase.. Fisch F, Fleites CM, Delenne M, Baudendistel N, Hauer B,. Turkenburg JP, Hart S, Bruce NC, Grogan G;. J Am Chem Soc. 2010;132:11455-11457.. [2]. 18576402. Structure and mechanism of an unusual malonate decarboxylase and. related racemases.. Okrasa K, Levy C, Hauer B, Baudendistel N, Leys D, Micklefield. J;. Chemistry. 2008;14:6609-6613. (from Pfam)

GO Terms:

Biological Process:: metabolic process (GO:0008152)

Molecular Function:: racemase activity, acting on amino acids and derivatives (GO:0036361)

Date:: 2024-08-14

Family Accession:: NF013353.5
Method:: HMM

Select item 3902323.

new record, indexing in progress

Family Accession:

Select item 3887904.

new record, indexing in progress

Family Accession:

Select item 3474175.

new record, indexing in progress

Family Accession:

Select item 3470966.

new record, indexing in progress

Family Accession:

Select item 236957.

glutamate racemase

Gene:: racE

GO Terms:

Biological Process:: metabolic process (GO:0008152)

Molecular Function:: glutamate racemase activity (GO:0008881)

Date:: 2024-05-02

Family Accession:: NF002035.0
Method:: HMM

Select item 163778.

glutamate racemase

This family consists of glutamate racemase, a protein required for making the UDP-N-acetylmuramoyl-pentapeptide used as a precursor in bacterial peptidoglycan biosynthesis. The most closely related proteins differing in function are aspartate racemases.

Gene:: murI

GO Terms:

Molecular Function:: glutamate racemase activity (GO:0008881)

Biological Process:: peptidoglycan biosynthetic process (GO:0009252)

Date:: 2021-04-27

Family Accession:: TIGR00067.1
Method:: HMM

Select item 163719.

RdgB/HAM1 family non-canonical purine NTP pyrophosphatase

Saccharomyces cerevisiae HAM1 protects against the mutagenic effects of the base analog 6-N-hydroxylaminopurine, which can be a natural product of monooxygenase activity on adenine. Methanococcus jannaschii MJ0226 and E. coli RdgB are also characterized as pyrophosphatases active against non-standard purines NTPs. E. coli RdgB appears to act by intercepting non-canonical deoxyribonucleotide triphosphates from replication precursor pools.[3]

Gene:: rdgB

GO Terms:

Biological Process:: DNA repair (GO:0006281)

Molecular Function:: dITP diphosphatase activity (GO:0035870)

Molecular Function:: XTP diphosphatase activity (GO:0036222)

Date:: 2024-02-27

Family Accession:: TIGR00042.1
Method:: HMM

Select item 803410.

XTP/dITP diphosphatase

Hydrolyzes non-standard nucleotides such as xanthine and inosine

GO Terms:

Biological Process:: nucleoside triphosphate catabolic process (GO:0009143)

Molecular Function:: nucleoside triphosphate diphosphatase activity (GO:0047429)

Date:: 2021-08-05

Family Accession:: NF011397.0
Method:: HMM

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