Protein Family Models

This entry represents flotillin-like protein FloA from bacteria. Bacterial flotillin-like proteins are found in membrane microdomains that may be equivalent to eukaryotic membrane rafts [1]. Similarly to eukaryotic flotillin proteins, flotillins in bacteria play an essential role in organising and maintaining the correct architecture of the functional membrane microdomains [2,3]. Bacillus subtilis has two flotillin paralogs, FloT and FloA. The absence of one of the flotillins has only minor effects, but the absence of both proteins has very severe effects: loss of proper cell shape, a defect in cell division [3]. [1]. 20713508. Functional microdomains in bacterial membranes.. Lopez D, Kolter R;. Genes Dev. 2010;24:1893-1902.. [2]. 25652542. Exploring the existence of lipid rafts in bacteria.. Bramkamp M, Lopez D;. Microbiol Mol Biol Rev. 2015;79:81-100.. [3]. 27362352. Super Resolution Fluorescence Microscopy and Tracking of. Bacterial Flotillin (Reggie) Paralogs Provide Evidence for. Defined-Sized Protein Microdomains within the Bacterial. Membrane but Absence of Clusters Containing Detergent-Resistant. Proteins.. Dempwolff F, Schmidt FK, Hervas AB, Stroh A, Rosch TC, Riese CN,. Dersch S, Heimerl T, Lucena D, Hulsbusch N, Stuermer CA,. Takeshita N, Fischer R, Eckhardt B, Graumann PL;. PLoS Genet. 2016;12:e1006116. (from Pfam)

Date:

2024-08-14

flotillin-like FloA family protein similar to Bacillus subtilis YqfA that is present exclusively in functional membrane microdomains and is homologous to eukaryotic lipid raft-specific flotillin proteins

Date:

2020-04-21

Gene:

floA

Date:

2020-10-26