Protein Family Models for Protein (Select 489512205) - Protein Family Models

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Items: 4

Select item 4284101.

type I phosphomannose isomerase catalytic subunit

This entry represents the catalytic domain of Phosphomannose isomerase type I enzymes (EC 5.3.1.8) which contains a zinc-binding site. It is composed of beta-strands connected by long loops in a jelly roll conformation [1]. [1]. 8612079. The x-ray crystal structure of phosphomannose isomerase from. Candida albicans at 1.7 angstrom resolution.. Cleasby A, Wonacott A, Skarzynski T, Hubbard RE, Davies GJ,. Proudfoot AE, Bernard AR, Payton MA, Wells TN;. Nat Struct Biol 1996;3:470-479. (from Pfam)

GO Terms:

Molecular Function:: mannose-6-phosphate isomerase activity (GO:0004476)

Molecular Function:: zinc ion binding (GO:0008270)

Date:: 2024-08-14

Family Accession:: NF042587.3
Method:: HMM

Select item 4065812.

new record, indexing in progress

Family Accession:

Select item 3662153.

new record, indexing in progress

Family Accession:

Select item 161334.

mannose-6-phosphate isomerase, class I

The names phosphomannose isomerase and mannose-6-phosphate isomerase are synonomous. This family contains two rather deeply branched groups. One group contains an experimentally determined phosphomannose isomerase of Streptococcus mutans as well as three uncharacterized paralogous proteins of Bacillus subtilis, all at more than 50 % identity to each other, plus a more distant homolog from Archaeoglobus fulgidus. The other group contains members from E. coli, budding yeast, Borrelia burgdorferi, etc.