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DapH/DapD/GlmU-related protein
Members of this family share a hexapeptide repeat-containing domain with acetyltransferases and succinyltransferases such as DapH, DapD, and GlmU.
LpxD N-terminal domain-containing protein
UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase (EC 2.3.1.-) catalyses an early step in lipid A biosynthesis: UDP-3-O-(3-hydroxytetradecanoyl)glucosamine + (R)-3-hydroxytetradecanoyl- [acyl carrier protein] -> UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + [acyl carrier protein] [1]. Members of this family also contain a hexapeptide repeat (Pfam:PF00132). This family constitutes the non-repeating region of LPXD proteins. [1]. 8366125. The firA gene of Escherichia coli encodes. UDP-3-O-(R-3-hydroxymyristoyl)-glucosamine N-acyltransferase.. The third step of endotoxin biosynthesis.. Kelly TM, Stachula SA, Raetz CR, Anderson MS;. J Biol Chem 1993;268:19866-19874. (from Pfam)
transferase-like hexapeptide repeat-containing protein
UDP-3-O-(3-hydroxymyristoyl)glucosamine N-acyltransferase
Adds the O-linked and N-linked 3(R)-hydroxy fatty acids to the glucosamine disaccharide during lipid A biosynthesis
This HMM describes LpxD, an enzyme for the biosynthesis of lipid A, a component oflipopolysaccharide (LPS) in the outer membrane outer leaflet of most Gram-negative bacteria. Some differences are found between lipid A of different species. This protein represents the third step from UDP-N-acetyl-D-glucosamine. The group added at this step generally is 14:0(3-OH) (myristate) but may vary; in Aquifex it appears to be 16:0(3-OH) (palmitate).
LpxD family protein
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