Protein Family Models

The KAP (after Kidins220/ARMS and PifA) family of predicted NTPases are sporadically distributed across a wide phylogenetic range in bacteria and in animals. Many of the prokaryotic KAP NTPases are encoded in plasmids and tend to undergo disruption to form pseudogenes. A unique feature of all eukaryotic and certain bacterial KAP NTPases is the presence of two or four transmembrane helices inserted into the P-loop NTPase domain. These transmembrane helices anchor KAP NTPases in the membrane such that the P-loop domain is located on the intracellular side [1]. [1]. 15128444. A novel family of P-loop NTPases with an unusual phyletic. distribution and transmembrane segments inserted within the. NTPase domain.. Aravind L, Iyer LM, Leipe DD, Koonin EV;. Genome Biol 2004;5:R30. (from Pfam)

Date:

2024-08-14

Date:

2024-08-14

guanosine monophosphate kinase (GMPK), also known as guanylate kinase (GKase)

Date:

2016-05-13

Members of this family are the enzyme guanylate kinase, also called GMP kinase. This enzyme transfers a phosphate from ATP to GMP, yielding ADP and GDP.

Gene:

gmk

Date:

2024-05-29