Protein Family Models

Domain found in uncharacterised family of membrane proteins. 1-3 copies found in each protein, with each copy flanked by transmembrane helices. Members of this family have a PH domain like structure [2]. [1]. 12625841. New Knowledge from Old: In silico discovery of novel protein. domains in Streptomyces coelicolor.. Yeats C, Bentley S, Bateman A;. BMC Microbiol 2003;3:3-3.. [2]. 19913036. Bacterial pleckstrin homology domains: a prokaryotic origin for. the PH domain.. Xu Q, Bateman A, Finn RD, Abdubek P, Astakhova T, Axelrod HL,. Bakolitsa C, Carlton D, Chen C, Chiu HJ, Chiu M, Clayton T, Das. D, Deller MC, Duan L, Ellrott K, Ernst D, Farr CL, Feuerhelm J,. Grant JC, Grzechnik A, Han GW, Jaroszewski L, Jin KK, Klock HE,. Knuth MW, Kozbial P, Krishna SS, Kumar A, Marciano D, McMullan. D, Miller MD, Morse AT, Nigoghossian E, Nopakun A, Okach L,. Puckett C, Reyes R, Rife CL, Sefcovic N, Tien HJ, Trame CB, van. den Bedem H, Weekes D, Wooten T, Hodgson KO, Wooley J, Elsliger. MA, Deacon AM, Godzik A, Lesley SA, Wilson IA.. J Mol Biol. 2010 Feb 12;396(1):31-46. Epub 2009 Nov 10. (from Pfam)

Date:

2024-08-14

This family, known as ROK (Repressor, ORF, Kinase) includes the xylose operon repressor, xylR, from Bacillus subtilis, Lactobacillus pentosus and Staphylococcus xylosus; N-acetylglucosamine repressor, nagC, from Escherichia coli; glucokinase from Streptomyces coelicolor; fructokinase from from Pediococcus pentosaceus, Streptococcus mutans and Zymomonas mobilis; allokinase and mlc from E. coli; and E. coli hypothetical proteins yajF and yhcI and the corresponding Haemophilus influenzae proteins. The repressor proteins (xylR and nagC) from this family possess an N-terminal region not present in the sugar kinases and which contains an helix-turn-helix DNA-binding motif. (from Pfam)

Date:

2024-08-14

Gene:

ppgK

Date:

2024-05-09