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aminoglycoside adenylyltransferase domain-containing protein
This domain is found at the C-terminal end of Aminoglycoside adenylyltransferase from Salmonella typhimurium (AadA) and other proteins associated with methicillin-resistant bacteria. AadA adenylates the 3''-hydroxyl group of the streptomycin glucosamine ring and the 9-hydroxyl group of the spectinomycin actinamine ring, mediating bacterial resistance to these antibiotics. This enzyme is organised into two domains: a N-terminal domain with a nucleotidyltransferase fold (Pfam:PF01909) and a C-terminal domain (this entry) which consists of five alpha-helices forming an up-and-down alpha-helical bundle. This domain undergoes small conformational changes upon binding of ATP and magnesium that play a key role in the binding of the antibiotic compounds [1,2]. [1]. 26527143. Structure of AadA from Salmonella enterica: a monomeric. aminoglycoside (3'')(9) adenyltransferase.. Chen Y, Nasvall J, Wu S, Andersson DI, Selmer M;. Acta Crystallogr D Biol Crystallogr. 2015;71:2267-2277.. [2]. 29871922. Structural mechanism of AadA, a dual-specificity aminoglycoside. adenylyltransferase from Salmonella enterica.. Stern AL, Van der Verren SE, Kanchugal P S, Nasvall J,. Gutierrez-de-Teran H, Selmer M;. J Biol Chem. 2018;293:11481-11490. (from Pfam)
nucleotidyltransferase domain-containing protein
Members of this family belong to a large family of nucleotidyltransferases [1]. This family includes kanamycin nucleotidyltransferase (KNTase) which is a plasmid-coded enzyme responsible for some types of bacterial resistance to aminoglycosides. KNTase in-activates antibiotics by catalysing the addition of a nucleotidyl group onto the drug. [1]. 7482698. DNA polymerase beta belongs to an ancient nucleotidyltransferase. superfamily.. Holm L, Sander C;. Trends Biochem Sci 1995;20:345-347. (from Pfam)
AadA family aminoglycoside 3''-O-nucleotidyltransferase
AadA family aminoglycoside 3''-O-nucleotidyltransferase such as streptomycin 3''-adenylyltransferase, which mediates bacterial resistance to the antibiotics streptomycin and spectomycin
aminoglycoside adenylyltransferase family protein
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