Protein Family Models

This family contains Cass2 from Vibrio cholerae, an integron-associated protein that has been shown [1] to bind cationic drug compounds with submicromolar affinity. Cass2 has been proposed to be representative of a larger family of independent effector-binding proteins associated with lateral gene transfer within Vibrio and other closely-related species. [1]. 21390267. Crystal structure of an integron gene cassette-associated. protein from Vibrio cholerae identifies a cationic drug-binding. module.. Deshpande CN, Harrop SJ, Boucher Y, Hassan KA, Di Leo R, Xu X,. Cui H, Savchenko A, Chang C, Labbate M, Paulsen IT, Stokes HW,. Curmi PM, Mabbutt BC;. PLoS One. 2011;6:e16934. (from Pfam)

Date:

2024-08-14

This family contains the small molecule binding domain of a number of different bacterial transcription activators [1]. This family also contains DNA gyrase inhibitors. The GyrI superfamily contains a diad of the SHS2 module, adapted for small-molecule binding [3]. The GyrI superfamily includes a family of secreted forms that is found only in animals and the bacterial pathogen Leptospira [3]. [1]. 10802742. Crystal structure of the Escherichia coli Rob transcription. factor in complex with DNA.. Kwon HJ, Bennik MH, Demple B, Ellenberger T;. Nat Struct Biol 2000;7:424-430.. [2]. 11948793. Crystal structure of the Escherichia coli SbmC protein that. protects cells from the DNA replication inhibitor microcin B17.. Romanowski MJ, Gibney SA, Burley SK;. Proteins 2002;47:403-407.. [3]. 15281131. The SHS2 module is a common structural theme in functionally. diverse protein groups, like Rpb7p, FtsA, GyrI, and. MTH1598/TM1083 superfamilies.. Anantharaman V, Aravind L;. Proteins. 2004;56:795-807. (from Pfam)

Date:

2024-08-14

GyrI-like domain-containing protein adopts a beta-barrel fold similar to the effector-binding region of AraC/XylS transcription activators and may bind a small molecule

Date:

2021-02-05