Protein Family Models

This family of holins is found in several staphylococcal and streptococcal bacteriophages. Holins are a diverse family of proteins that cause bacterial membrane lysis during late-protein synthesis. It is thought that the temporal precision of holin-mediated lysis may occur through the buildup of a holin oligomer which causes the lysis [1]. [1]. 11459934. Holins kill without warning.. Grundling A, Manson MD, Young R;. Proc Natl Acad Sci U S A 2001;98:9348-9352. (from Pfam)

Date:

2024-08-14

COG5546 family protein

Date:

2017-03-02

Phage proteins for bacterial lysis typically include a membrane-disrupting protein, or holin, and one or more cell wall degrading enzymes that reach the cell wall because of holin action. Holins are found in a large number of mutually non-homologous families.

Date:

2022-10-24