Protein Family Models

IreB is a cytosolic 10.5-kDa protein that is highly conserved among low-GC Gram-positive bacteria . Studies of E. faecalis mutants lacking ireB revealed that IreB acts downstream of IreK as a negative regulator of cephalosporin resistance in E. faecalis. IreB can be modified by phosphorylation in vivo, and mutations that prevent modification at the known sites of phosphorylation (T4 and T7) influence the ability of IreB to modulate cephalosporin resistance. Furthermore, mutations that impair dimerization abolish the regulation of cephalosporin resistance [1]. [1]. 28551334. Structure and Dimerization of IreB, a Negative Regulator of. Cephalosporin Resistance in Enterococcus faecalis.. Hall CL, Lytle BL, Jensen D, Hoff JS, Peterson FC, Volkman BF,. Kristich CJ;. J Mol Biol. 2017;429:2324-2336. (from Pfam)

Date:

2024-08-14

IreB family regulatory phosphoprotein similar to IreB, which was characterized in Enterococcus faecalis as a small protein, well-conserved in the Firmicutes. It belongs to a system that includes the Ser/Thr protein kinase IreK, and phosphatase IreP, undergoes phosphorylation on threonine residues, and is involved in regulating cephalosporin resistance. This family was previously named DUF965

Date:

2017-11-30

IreB (EF1202) was characterized in Enterococcus faecalis as a small alpha-helical protein (PDB: 5US5), well-conserved in the Firmicutes. It belongs to a system that includes the Ser/Thr protein kinase IreK, and phosphatase IreP, undergoes phosphorylation on threonine residues, and is involved in regulating cephalosporin resistance. This family was previously named DUF965 by Pfam model PF06135. The gene symbol Ire signifies Intrinsic Resistance of Enterococci.

Date:

2020-10-26